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“Our purpose is to grasp woman reproductive ageing, and why fertility fast declines starting up within the mid-30s,” states Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata works.
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The DNA in a human oocyte encompasses some 15 million nucleosomes — wrapping two times all over each one — forming an organized structure named chromatin.
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This enables the oocytes to pause their growth and enter a Keeping sample, which lasts into the mouse’s adulthood. In mice lacking PRC1, the oocytes didn’t pause their development; as a substitute, they withered and died in just a thirty day period, leaving the mice forever infertile.
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